Treatment-Resistant Depression: An Update on Management Strategies-View Presentation Slides

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The document presented is from a webinar by the American Psychiatric Association discussing management strategies for treatment-resistant depression (TRD). The session provides contemporary insights and strategies for dealing with TRD—a challenging condition faced by clinicians managing depressive disorders. <br /><br />The webinar outlines key interventions for addressing TRD, including pharmacological augmentation, neuromodulation techniques such as Transcranial Magnetic Stimulation (TMS) and Electroconvulsive Therapy (ECT), and newer methodologies involving ketamine and esketamine use. The presentation highlights the complexity of managing treatment-resistant depression, noting that about 20% of patients with depressive disorders may develop treatment resistance.<br /><br />The discussion covers various risk factors for depression, including gender differences, socioeconomic status, and lifestyle factors. Traditional antidepressants show limited success, with a high remission rate for initial treatments being only about 30%. In cases of TRD, augmenting treatments with atypical antipsychotics or therapies like ECT can be pursued. ECT is considered highly effective yet underutilized due to stigma and historical misuse.<br /><br />TMS is underlined as a significant non-invasive treatment option, with different types and configurations (like figure-eight coils) to enhance cognitive processes. Meanwhile, ketamine and its derivative, esketamine, present promising new approaches with rapid effects on depressive symptoms, although they require careful monitoring during administration.<br /><br />The session focuses on providing actionable knowledge for practitioners regarding pharmacological strategies, economic implications, and safety assessments related to these interventions. Also included are logistics for continuing education credit, resources for further learning, Q&A participation protocols, resources for additional questions, and an upcoming webinar focusing on ECT.

Keywords

treatment-resistant depression

American Psychiatric Association

pharmacological augmentation

Transcranial Magnetic Stimulation

Electroconvulsive Therapy

ketamine

esketamine

neuromodulation

depressive disorders

antidepressants