Description
The key to keeping patients on clozapine is management of adverse effects and optimizing response. This presentation provides detailed practical information about strategies to mitigate weight gain, how to distinguish benign fever from other conditions (myocarditis, nephritis), and when to suspect cardiomyopathy. There is also a discussion of why routine seizure prophylaxis with divalproex is not necessary and might be harmful, and methods for addressing nonresponse.
Format
Recorded webinar, non-interactive, self-paced distance learning activity with post-test.
This presentation was recorded on June 1, 2020.
Learning Objectives
Discuss the rationale for and dosing of prophylactic use of metformin to manage clozapine related weight gain.
Identify that seizures are easily managed and should never be a reason to discontinue clozapine treatment.
Express the conclusions that, due to the low prevalence of seizures, prophylactic anticonvulsants should not be used as these will be unnecessary in 98% of patients.
Diagnose myocarditis and interstitial nephritis, and distinguish these from benign fever and benign eosinophilia
Recognize the need for evaluation of cardiomyopathy
Explain that there is a known incidence of hematologic abnormalities other than neutropenia, including leukocytosis, neutrophilia, thrombocytosis, thrombocytopenia and anemia
Manage inadequate clozapine response
Outline
- Introduction & Learning Objectives
- Fever, Myocarditis, Interstitial Nephritis, Cardiomyopathy
- Managing Inadequate Response
Target Audience
Psychiatrist, Physician (Non-Psychiatric)
Instruction Level
Intermediate
Estimated Time to Complete
Estimated Duration: 1.0 hour
Program Start Date: July 30, 2025
Program End Date: July 30,2028
Ongoing Interdisciplinary Discussion Board
After completing the course, engage with colleagues in the mental health field through the Webinar Roundtable Topics discussion board. This is an easy way to network and share ideas with other clinicians who participate in this webinar. Access through the discussion tab.
How to Earn Credit
After completing the evaluation, participants will have the opportunity to claim their hours of participation and download the appropriate certificate. Physicians may obtain an official CME certificate, other healthcare professionals may receive a CE certificate (as applicable), and all other attendees may generate a certificate of participation. Each certificate will reflect the event date and total hours earned.
Continuing Education Credit
In support of improving patient care, American Psychiatric Association (APA) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
Physicians
The APA designates this live event for a maximum of 1.00 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Faculty and Planner Disclosures
The American Psychiatric Association adheres to the ACCME's Standards for Integrity and Independence in Accredited Medical Education. Any individuals in a position to control the content of a CME activity - including faculty, planners, reviewers, or others - are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.
Faculty
- Jonathan Meyer, MD, Clinical Professor of Psychiatry, University of California, San Diego. Disclosures - Consultant: Acadia Pharmaceuticals, Alkermes, Abbvie, Intra-Cellular Therapies, Neurocrine; Speaker Bureau: Acadia Pharmaceuticals, Alkermes, Janssen Pharmaceutica, Neurocrine, Otsuka America, Inc., Sunovion Pharmaceuticals, and Teva Pharmaceutical Industries Ltd.
Program Planners
- Tristan Gorrindo, MD, American Psychiatric Association. Reports no financial relationships with commercial interests.
- Teri Brister, PhD, National Alliance on Mental Illness. Reports no financial relationships with commercial interests.
Accessibility for Participants with Disabilities
The American Psychiatric Association is committed to ensuring accessibility of its website to people with disabilities. If you have trouble accessing any of APA’s online resources, please contact us at 202-559-3900 for assistance.
Technical Requirements
This internet-based CME activity is best experienced using any of the following:
The latest and 2nd latest public versions of Google Chrome, Mozilla Firefox, or Safari
Internet Explorer 11+
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Optimal System Configuration:
Browser: Google Chrome (latest and 2nd latest version), Safari (latest and 2nd latest version), Internet Explorer 11.0+, Firefox (latest and 2nd latest version), or Microsoft Edge (latest and 2nd latest version)
Operating System: Windows versions 8.1+, Mac OS X 10.5 (Leopard) +, Android (latest and 2nd latest version), or iOS/iPad OS (latest and 2nd latest version)
Internet Connection: 1 Mbps or higher
Minimum Requirements:
Windows PC: Windows 8.1 or higher; 1 GB (for 32-bit)/2 GB (for 64-bit) or higher RAM; Microsoft DirectX 9 graphics device with WDDM driver; audio playback with speakers for programs with video content
Macintosh: Mac OS X 10.5 or higher with latest updates installed; Intel, PowerPC G5, or PowerPC G4 (867MHz or faster) processor; 512 MB or higher RAM; audio playback with speakers for programs with video content
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